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Red Blood Cells Variations in Shape, Size & Structure

Presentation Notes on Erythrocyte (RBC) Variation causes in Shape, Size & Structure for Medical Biology Students

VARIATIONS IN SIZE OF RED BLOOD CELLS

The size of the red blood cells alters in various conditions.

Microcytes

Microcytes are the red blood cells of small size and are present in the following conditions:

  1. Iron deficiency anemia
  2. Prolonged forced breathing and
  3. Increased osmotic pressure in blood
Macrocytes

Macrocytes are the red blood cells with large macrocytes are present in the following conditions:

  1. Megaloblastic anemia
  2. Muscular exercise and
  3. Decreased osmotic pressure in blood
Anisocytes

The red blood cells with unequal size are called anisocytes. This happens in pernicious anemia.

VARIATIONS IN SHAPE OF RED BLOOD CELLS


The following are the abnormal shape of red blood cells. Some of these abnormal shapes of the red occur in different types of anemia.

  1. Crenation : Shrinkage as in hypertonic solution.
  2. Spherocytosis : Globular form as in hypotonic solution
  3. Elliptocytosis : Elliptical shape as in certain types of anemia
  4. Sickle cell : Crescentic shape as in sickle cell anemia
  5. Poikilocytosis : Unequal shapes due to deformed cell membrane. The shape of flask, hammer or unusual shape.
VARIATIONS IN STRUCTURE OF RED BLOOD CELLS

1. Punctate Basophilism

In this condition, dots of basophilic materials (appear in the red blood cells giving a stripped appearance. This occurs in conditions like lead poisoning.

2. Ring

Ring or twisted strands of basophilic material the periphery of the red blood cells. This is also called the Goblet ring. This appears in the red blood cells in certain types of anemia.

3. Howell-Jolly Bodies

In certain types of anemia, some nuclear fragments are present in the ectoplasm of the red blood cells. These nuclear fragments are called Howell-Jolly bodies.


Download Notes on Red Blood Cells Variations

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