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Beta Cell Dysfunction in Type 2 Diabetes

Presentation Notes on Insulin Resistance and Beta Cell Dysfunction mechanism in Type 2 Diabetes with treatment for medical & Biology Students in word / .doc / .ppt format

Insulin resistance & b - Cell Dysfunction Mechanism:

b - Cell dysfunction in type 2 diabetes reflects the inability of these cells to adapt themselves to the long  term demands of peripheral insulin resistance and increased insulin secretion. In states of insulin resistance, insulin secretion is initially higher for each level of glucose than in controls. This hyperinsulinemic state is a compensation for peripheral resistance and can often maintain normal plasma glucose for years. Eventually, however,

b - cell compensation becomes inadequate, and there is progression to overt diabetes. The underlying basis for failure of b - cell adaptation is not known, although it is postulated that several mechanisms, including adverse effects of high circulating free fatty acids (“lipotoxicity”) or chronic hyperglycemia (“glucotoxicity”), may play a role. b - Cell dysfunction in type 2 diabetes manifests itself as both qualitative and quantitative defects.

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