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HIV AIDs Cure Articles on Blockade of Viral Peptide

Health Care Presentation on HIV AIDs prevention method by preventing HIV Virus fusing into Human Cell for medical & Biology Students in word/ .doc/.ppt Format


 
BLOCKADE OF VIRAL PEPTIDE HELICES PREVENTS HIV FROM FUSING WITH THE HOST CELL

Penetration of the human immunodeficiency virus (HIV) into human host cells involves not only the CD4 surface molecule, but also other receptors (coreceptors). It is known now that there are three key stages in HIV entry of target cells: attachment of virus envelope protein to CD4; binding of virus envelope protein to a coreceptor; and then fusion of virus and host cell membranes. The beta-chemokine coreceptor CCR5 facilitates the entry in particular of HIV-1 strains that predominantly infect macrophages, while the CXCR4 coreceptor facilitates the entry of HIV strains that predominantly infect T lymphocytes.

Now that some of those HIV-1-infected individuals who fail to develop end-stage


HIV disease or whose progression is considerably slowed have been found to have mutations in the region of the CCR5 gene, intensive efforts are being made to find ways of blocking these coreceptors and thus preventing the HIV virus from entering host cells. Another approach makes use of synthetic peptides. By binding to the transmembrane gp41 region of the viral envelope protein, these peptides prevent the viral membrane from fusing with that of the host cell.

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