Presentation Notes on Insulin Resistance and Beta Cell Dysfunction
mechanism in Type 2 Diabetes with treatment for medical & Biology Students
in word / .doc / .ppt format
Insulin resistance & b - Cell
Dysfunction Mechanism:
b - Cell dysfunction in type 2
diabetes reflects the inability of these cells to adapt themselves to the
long term demands of peripheral insulin
resistance and increased insulin secretion. In states of insulin resistance,
insulin secretion is initially higher for each level of glucose than in
controls. This hyperinsulinemic state is a compensation for peripheral
resistance and can often maintain normal plasma glucose for years. Eventually,
however,
b - cell compensation becomes
inadequate, and there is progression to overt diabetes. The underlying basis
for failure of b - cell adaptation is
not known, although it is postulated that several mechanisms, including adverse
effects of high circulating free fatty acids (“lipotoxicity”) or chronic
hyperglycemia (“glucotoxicity”), may play a role. b - Cell
dysfunction in type 2 diabetes manifests itself as both qualitative and
quantitative defects.
Download Information on Beta Cell Dysfunction in Type 2 Diabetes
No comments:
Post a Comment