Presentation Notes of Mean Corpuscular Hemoglobin Volume
Concentration & red Blood Cell Indices Calculation with interpretation in
word/ .ppt/ .pdf Format
1. Mean Corpuscular Volume (MCV)
4. Colour Index (Cl)
CALCULATION OF BLOOD INDICES
Colour Index
The results of these indices indicate that the persor is suffering from microcytic hypochromic anemia, commonly occurs during the deficiency of iron.
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BLOOD INDICES
Blood indices are specifically
meant for erythrocytes. The number, shape, volume and the colour of the red
blood cells indicate the quality of blood. So, these features are named as
blood indices.
IMPORTANCE OF
BLOOD INDICES
Following are the various blood
indices:
1. Mean Corpuscular Volume (MCV) .
2. Mean Corpuscular Hemoglobin (MCH)
3. Mean Corpuscular Hemoglobin Concentration
(MCHC)
4. Colour Index (Cl).
CALCULATION
OF BLOOD INDICES
Blood
indices are calculated by using different formula. These calculations require
the values of RBC count, hemoglobin content and PCV. For example, the values
from the blood of a male subject are:
RBC
count = 4 millions/cu
mm.
Hemoglobin
content = 8 g%
PCV = 30%
Colour
index, MCV, MCH and MCHC are calculated as follows:
1. Mean Corpuscular Volume (MCV)
MCV is the average volume of a
single red blood cells. it is expressed in cubic microns (cu.μ)The normal is 90
cu.μ(78 to 90 cu.μ. When MCV is increased, the cell is known as a macrocyte and
when it is decreased, the cell is called microcyte. MCV is more in pernicious
anemia and megaloblastic anemia in which the red blood cells are macrocytic in
nature. MCV is less in microcytic anemia.
2. Mean Corpuscular Hemoglobin (MCH)
This is the quantity or amount of
hemoglobin present in one red blood cell. It is expressed in micro micro gram
or Pico gram (pg). The normal value of MCH is 30 pg (27 to 32 pg.). It
decreases or remains normal in pernicious anemia and megaloblastic anemia, in
which red blood cells are macrocytic and normochromic or hypochromic. It
decreases in hypochromic anemia. When MCH is normal, it is called normochromic
state.
3. Mean
Corpuscular Hemoglobin Concentration (MCHC)
This is the concentration of
hemoglobin in one red blood cell. It is the amount of hemoglobin expressed in
relation to the volume of one red blood cell. So, the unit of expression is
percentage. This is the most important absolute value in the diagnosis of
anemia. The normal value of MCHC is 30% (30 to 38%). It is decreased in iron
deficiency anemia in which, red blood cells are microcytic and hypochromic.
4. Colour Index (Cl)
This is the ratio between the
percentage of hemoglobin and the percentage of red blood cells in the blood.
Actually, this is the average hemoglobin content in one cell of a patient
compared to the average hemoglobin content in j one cell of a normal person.
The normal colour index is 1.0 (0.8 to 1.2). This was widely used in olden
days. However, it is useful in determining the type of anemia. It is raised in
pernicious anemia and megaloblastic anemia. It is reduced in iron deficiency
anemia. And, it is normal in normocytic normochromic anemia.
CALCULATION OF BLOOD INDICES
Blood
indices are calculated by using different formula. These calculations require
the values of RBC count, hemoglobin content and PCV. For example, the values
from the blood of a male subject are:
RBC
count = 4 millions/cu
mm.
Hemoglobin
content = 8 g%
PCV = 30%
Colour
index, MCV, MCH and MCHC are calculated as follows:
Colour Index
This
is calculated by dividing the hemoglobin percentage by the red blood cell count
percentage.
Thus,
the Colour Index = Hemoglobin% / RBC
%
Hemoglobin % = Hemoglobin content in the subject
Normal
hemoglobin content = 53.3%
RBC % =
RBC count in the subject× 100
Normal RBC count :-
(4 millions/cu mm) / 5
millions/cu mm x 100 = 80%
By
using these two, Cl is calculated
Colour Index = Hemoglobin% 53.3% /
RBC% 80%
Colour Index =
0.67
Mean Corpuscular Volume
MCV = Volume of packed cells in ml per 1,000 ml
of blood / Red blood cells in millions per cu mm of blood
PCV
in 1000 ml or in 100 ml x 10
RBC
count in millions/cu mm
30 x
10 M.CV / 4 = 75 cu μ
Mean Corpuscular
Hemoglobin
MCH = Hemoglobin in grams per
1000 ml of blood / RBC count in millions/cu mm
= 80 pg / 4
Thus,
MCH = 20 pg. or micro micro gram.
Mean Corpuscular Hemoglobin Concentration
MCHC
= Hemoglobin in grams/ 100 ml of
blood × 100
PCV in 100 ml of
blood =
800 / 30 %
Thus,
MCHC = 26.67%.
Results
Cl = 0.67
(Normal
MCV = 75 cuμ (Normal
MCH =20pg (Normal
MCHC =26.67 (Normal
The results of these indices indicate that the persor is suffering from microcytic hypochromic anemia, commonly occurs during the deficiency of iron.
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