MAGNESIUM (Mg):
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Magnesium
is found both in intracellular and extracellular fluids. Total body magnesium
is about 20 g, 75% of which is complexed with calcium in bone.
Source:
- Green vegetables, potatoes, almond,
cheese, cereals, beans and almost all animal tissues.
Daily requirement:
Absorption:
- Absorption of magnesium takes place
primarily in the small bowel by a specific carrier mechanism.
- Factors which increase the absorption
of magnesium are vitamin D, PTH, high-protein intake, neomycin therapy.
- Factors which decrease the
absorption are increased calcium intake, fatty acids, phytates and
phosphate.
Functions:
- Involved in enzyme action. Magnesium
is the cofactor of many enzymes requiring ATP. Alkaline phosphatase,
hexokinase, fructokinase, adenylate cyclase, cAMP-dependent kinase need
magnesium. Magnesium forms ATP-Mg2+ complexes and binds to the enzymes.
- Required in neuromuscular activity.
- An important constituent of bone and
teeth
- Normal serum blood level is 2-3 mg/
dl (1-1.5mmol/l).
Clinical manifestations:
- Deficiency of magnesium causes
muscular tremor, confusion, vasodilation and hyperirritability.
Hypermagnesaemia is observed in:
- Hypothyroidism
- Diabetic mellitus
- Acute renal failure
Hypomagnesaemia is seen in:
- Hyperthyroidism
- Chronic alcoholism
- Malnutrition
- Prolonged use of diuretics
- Portal cirrhosis
Toxicity due to the increased use of
magnesium-containing laxatives and antacids has been reported in the elderly.
The chief symptoms are drowsiness, lethargy and weakness.
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